abstract：:The terminal complement complex has been implicated in the development of glomerular injury in both experimental and, indirectly, in human glomerulonephritis. Recent data suggests that the terminal complement complex in human glomerulonephritis may be in the cytolytically inactive SC5b-9 form which also contains S-pro...

journal_title：Pathology

authors： Murphy BF,Davies DJ,Morrow W,d'Apice AJ

更新日期：1989-10-01 00:00:00

abstract：:Lymphomatous involvement of skin usually manifests as plaques, maculopapules, papulonodules, tumorous masses or ulcerated eruptions. We report an unusual case in which the cutaneous relapse of nasal T-cell lymphoma clinically mimicked erythema multiforme by the abrupt onset of lesions and the presence of targetoid and...

journal_title：Pathology

authors： Chan JK,Sin VC,Ng CS,Lau WH

更新日期：1989-07-01 00:00:00

abstract：:The intimal thickness of the coronary arteries of humans less than 20 years of age was compared with that 9 other species. It was found that humans were unique amongst the species studied in showing substantial intimal thickening at an early age. The intimal thickening was associated with defects of the internal elast...

journal_title：Pathology

authors： Sims FH

更新日期：1989-04-01 00:00:00

abstract：:The causes and pathogenesis of severe childhood pneumonia in a developing country were studied in lungs removed at autopsy from 119 Bangladeshi children who presented with pneumonia and/or diarrhea. Pneumonia was observed in 93 patients. Morphologic features included acute alveolar exudate in 51% (of the 93 patients),...

journal_title：Pathology

authors： Tomashefski JF Jr,Butler T,Islam M

更新日期：1989-04-01 00:00:00

abstract：:Thirteen patients with Aeromonas species septicemia were seen at Westmead Hospital between 1983 and 1987. In 10 patients (77%) septicemia was caused by A. sobria, and in 3 (23%) by A. hydrophila, A. caviae was not isolated. Chronic underlying illness was present in 10 patients (77%), hematological malignancy being the...

journal_title：Pathology

authors： Dryden M,Munro R

更新日期：1989-04-01 00:00:00

abstract：:The estrogen receptor (ER) content of breast carcinoma is generally accepted as valuable in predicting clinical outcome and tumour response to hormonal manipulation. We applied a new immunocytochemical assay for estrogen receptors (Abbott ERICA Monoclonal) to 20 breast tumours, and examined the efficacy of 16 fixation...

journal_title：Pathology

authors： Raymond WA,Leong AS

更新日期：1988-10-01 00:00:00

abstract：:Statistical methods have been used to determine an optimal approach to the definition of the reference range for CD4 ("helper") and CD8 ("suppressor/cytotoxic") T cell numbers and the CD4/CD8 ratio in the peripheral blood. A graphical presentation of the absolute values for CD4 and CD8 for 85 healthy blood donors show...

journal_title：Pathology

authors： Zachar V,Mikulecky M,Mayer V,Mackay I,Frazer I

更新日期：1988-10-01 00:00:00

abstract：:The estimation of plasma alanine aminotransferase (ALT) has been proposed as a surrogate test to identify potential non-A, non-B hepatitis carriers in blood donor populations. This report describes an ALT screening procedure which uses wells of microtitration trays as reactant vessels. The method utilizes a rate readi...

journal_title：Pathology

authors： Hyland CA,Douglas R,Mazzocchi R,Young IF

更新日期：1988-07-01 00:00:00

abstract：:A case of solitary cervical intramedullary schwannoma with an extramedullary extension is reported. This case demonstrates the difficulty of radiologic diagnosis of these tumours and the necessity for pre-treatment biopsy. ...

journal_title：Pathology

authors： Garen PD,Collett MG,Harper CG

更新日期：1988-07-01 00:00:00

abstract：:A fatal case of multiple sulfatase deficiency in a 10-year-old girl is reported. In this rare disease, which is inherited as an autosomal recessive, features of metachromatic leukodystrophy and of mucopolysaccharidoses occur together. The white matter suffers progressive destruction with sulfatides accumulating in mac...

journal_title：Pathology

authors： Kepes JJ,Berry A 3rd,Zacharias DL

更新日期：1988-07-01 00:00:00

abstract：:In contrast to Caucasians, Japanese people have a relatively high incidence of malignant melanoma in the oral cavity and volar-subungual skin. The classification of oral melanoma has not been established. We report 7 new cases of oral melanoma, with a review of 36 cases, published in Japan, between 1970 and 1984. Most...

journal_title：Pathology

authors： Umeda M,Mishima Y,Teranobu O,Nakanishi K,Shimada K

更新日期：1988-07-01 00:00:00

abstract：:A calcified nodule on the liver of a 62-year-old man from North Carolina, USA, contained a degenerated nymph of Linguatula serrata. The nodule was incidentally discovered at laparotomy for malignant lymphoma and cholelithiasis. The cuticle was all that remained of the parasite, but sclerotized openings and large spine...

journal_title：Pathology

authors： Baird JK,Kassebaum LJ,Ludwig GK

更新日期：1988-04-01 00:00:00

abstract：:Monoclonal antibodies have been raised against components of glomerular immune deposits in experimental glomerulonephritis and idiopathic human glomerulonephritis. An accelerated model of chronic serum sickness in the rat using cationized human serum albumin was employed to obtain renal tissue with capillary loop and ...

journal_title：Pathology

authors： Murphy BF,d'Apice AJ

更新日期：1988-04-01 00:00:00

abstract：:Murine monoclonal antibodies to human myeloid cell surface differentiation antigens were prepared using the myelomonocytic leukemia cell line RC-2A as immunogen. Using a highly sensitive colorimetric assay, antibodies were selected as myeloid-associated based on their binding to RC-2A cells, but not to cells of the au...

journal_title：Pathology

authors： Lyons AB,Cooper SJ,Cole SR,Ashman LK

更新日期：1988-04-01 00:00:00

abstract：:The clinical and laboratory features of a patient with a recently recognized new variant of von Willebrand's disease are presented. The importance of this variant is that it is associated with a clinically significant bleeding diathesis but with a normal skin bleeding time, PTTK, factor VIIIc and platelet aggregation ...

journal_title：Pathology

authors： Wylie B,Gibson J,Uhr E,Kronenberg H

更新日期：1988-01-01 00:00:00

abstract：:A retrospective study of gallbladders submitted as surgical specimens over a period of fifteen years (1972-1986) was performed in the Department of Pathology, Queen Mary Hospital, Hong Kong. Seven thousand nine hundred and ten gallbladders were examined. A total of 253 more unusual and significant pathological lesions...

journal_title：Pathology

authors： Chan KW

更新日期：1988-01-01 00:00:00

abstract：:Sera from 82 patients with acute or chronic hepatitis and 40 chronic carriers of hepatitis B were examined by ELISA and immunoblotting for reactivity with the glycolytic enzyme aldolase. The results of the ELISA tests, expressed as a percentage of a positive control, were compared to those obtained with sera from 39 p...

journal_title：Pathology

authors： Brown C,Toh BH,Pedersen JS,Clarke FM,Mackay IR,Gust I

更新日期：1987-10-01 00:00:00

abstract：:We evaluated an immunoradiometric assay for serum TSH (IRMA-TSH) and compared it with established indices of thyroid function in 208 patients with either frank thyroid disease, conditions of abnormal thyroxine protein binding, or conditions which are known to produce discordant thyroid results, viz. pregnancy or estro...

journal_title：Pathology

authors： McLellan GH,Riley WJ,Summers MB,Sudholz P,Hickman PE

更新日期：1987-07-01 00:00:00

abstract：:A 5-year-old Chinese boy had dull pain in his right knee for about one year. An intraosseous osteolytic lesion in the metaphysis of the right lower femur was curetted. The diagnosis of desmoplastic fibroma, possibly the first in a Hong Kong Chinese, was based on the clinical, radiological and histological findings. Ab...

journal_title：Pathology

authors： Chan KW,Pun WK,Choi CH

更新日期：1987-04-01 00:00:00

abstract：:Cervical biopsies obtained by colposcopic direction from 358 women were histologically examined for squamous dysplasia (cervical intra-epithelial neoplasia; CIN) and human papillomavirus (HPV) infection. Of the 358 biopsies, 136 were stained by an immunoperoxidase method using an antiserum against genus-specific (comm...

journal_title：Pathology

authors： Sterrett GF,Alessandri LM,Pixley E,Kulski JK

更新日期：1987-01-01 00:00:00

abstract：:Proliferation of isolated hepatocytes in long-term splenic implants was assessed by flash labelling with a 1 pulse of tritiated thymidine (3H TdR). Cell kinetics showed that the basal labelling index was 0.9% which was greater than normal non-regenerating liver. Twenty four hours following partial hepatectomy the labe...

journal_title：Pathology

authors： Gupta S,Johnstone R,Darby H,Selden C,Price Y,Hodgson HJ

更新日期：1987-01-01 00:00:00

abstract：:Paracetamol in serum was assayed by a new enzymatic method, and the results compared with a high performance liquid chromatographic method. Results by the two procedures agreed well (t = 0.05). The correlation coefficient was 0.999, and the slope and intercept by Deming analysis were 0.975 and 0.003 mmol/l respectivel...

journal_title：Pathology

authors： Slater S

更新日期：1987-01-01 00:00:00

abstract：:The cell surface markers of 75 cases of non-Hodgkin's lymphoma were studied on cryostat sections using a panel of monoclonal antibodies. Forty-nine cases (65.3%) were found to express a B-cell phenotype, 23 cases (30.7%) a T-cell phenotype, 1 case (1.3%) a histiocytic phenotype and 2 cases (2.7%) no demonstrable surfa...

journal_title：Pathology

authors： Ng CS,Chan JK,Lo ST,Poon YF

更新日期：1986-10-01 00:00:00

abstract：:One thousand sera shown to be reactive by one of two commercial enzyme linked immunosorbent assays (ELISA) for antibodies to the AIDS virus were referred to the NSW State Reference Laboratory for confirmatory assays. Each serum was retested by two commercial ELISA systems (Abbott and ENI), the ENI exclusionary H9 ELIS...

journal_title：Pathology

authors： Imrie AA,Kehrer S,Smith GW,Penny R,Cooper DA

更新日期：1986-10-01 00:00:00

abstract：:A total of 52 of 238 patients (22%) with non-Hodgkin's lymphoma presented with disease in a primary extranodal site. The gastrointestinal tract was the commonest site involved (50%) and diffuse large cell was the commonest histological sub-type of the lymphoma (64%). Survivorship analysis of these patients, treated pr...

journal_title：Pathology

authors： Manoharan A,Smart RC,Pitney WR

更新日期：1986-10-01 00:00:00

abstract：:We have devised a simple, sensitive quantitative method for the determination of serum methemalbumin. The method uses a modified Allen correction to correct the alpha band of methemalbumin at 623 nm for background turbidity. The technique is robust and is more sensitive than Schumm's test. ...

journal_title：Pathology

authors： Cowley DM,Powell VR

更新日期：1986-07-01 00:00:00

abstract：:Tissue from the epiphyseal plate of a patient with Morquio type A syndrome (mucopolysaccharidosis type IVA) was studied by undecalcified histological and electron microscopical techniques. Cartilage cells in the plate were vacuolated to a variable degree. The orderly proliferating structure of the epiphyseal plate was...

journal_title：Pathology

authors： McClure J,Smith PS,Sorby-Adams G,Hopwood J

更新日期：1986-04-01 00:00:00

abstract：:Hypercalcemia is a common biochemical abnormality. It is usually possible to make a presumptive diagnosis of its cause by relatively simple means. In a large majority of cases this involves differentiating between primary hyperparathyroidism and malignancy-associated hypercalcemia. Clinical evaluation and parathyroid ...

journal_title：Pathology

authors： Mason RS

更新日期：1986-04-01 00:00:00

abstract：:The clinical course and biopsy findings of twenty-one patients with IgA nephropathy, followed up for a mean period of 37.4 mth (range 24-54 mth) after diagnosis, were reviewed retrospectively to determine whether the clinical presentations, the laboratory findings or histopathologic changes have prognostic implication...

journal_title：Pathology

authors： Ng WL,Loke SL,Yeung CK,Kwan S,Chan KW,Chan MK

更新日期：1986-01-01 00:00:00

abstract：:Measurement of extracellular hemoglobin is useful for assessing the relative success of different blood storage strategies. The test is now also included in routine quality assurance procedures. With the recent trend towards transfusion of concentrated red cells resuspended in "additive" solutions, a safe and efficien...

journal_title：Pathology

authors： Raftos JE,Stewart IM,Lovric VA

更新日期：1986-01-01 00:00:00

abstract：:A review of the morphological and metabolic interactions between hepatocytes, the various sinusoidal cells and sinusoidal blood is presented. This field of investigation is rapidly expanding, with widespread implications in the regulation of physiological processes and diseases in the liver and other organs. Although ...

journal_title：Pathology

authors： Fraser R,Day WA,Fernando NS

更新日期：1986-01-01 00:00:00

abstract：:Distinct differences in the extent and progression of the lateral and epicardial boundaries of evolving regional infarcts were demonstrated in isolated rabbit hearts. Ischemia was produced by interrupting (0-240 minutes) flow in the ventral interventricular branch of the left coronary artery, whilst the remainder of t...

journal_title：Pathology

authors： Sage MD,Gavin JB

更新日期：1985-10-01 00:00:00

abstract：:The clinical and autopsy findings in a premature baby who died of acute renal failure after therapy with gentamicin (5 mg/kg/day) and penicillin are presented. The serum gentamicin concentration had reached toxic levels when anuria developed. Numerous periodic acid Schiff (PAS) positive, diastase resistant cytoplasmic...

journal_title：Pathology

authors： Chan KW,Ng WL

更新日期：1985-07-01 00:00:00

abstract：:Changes in the contracture and stiffness of ventricular walls during ischemia and their effect on vascular reperfusion were studied in isolated rat hearts. Global ischemia was induced by stopping the flow of oxygenated perfusate for 60 min. Contracture pressures generated against water-filled left ventricular balloons...

journal_title：Pathology

authors： Humphrey SM,Gavin JB

更新日期：1985-07-01 00:00:00

abstract：:In the management of rheumatic diseases, peptic ulceration associated with anti-inflammatory drug therapy is a major problem and seriously limits the usefulness of these agents. In acute experiments with a guinea pig total gastric pouch preparation, gastric damage induced by the prostaglandin synthetase inhibitor indo...

journal_title：Pathology

authors： Maclaurin BP,Watts C,Palmer DG

更新日期：1985-07-01 00:00:00

abstract：:The results of semi-solid cultures of fresh biopsy material from 86 primary human melanomas are reported. Detailed histological assessments by Professor McGovern were available for 80 of the 86 melanomas, and these were compared with the growth characteristics of each specimen. Significant correlations were found betw...

journal_title：Pathology

authors： Vincent PC,Joyce RM,Croaker G,Young GA,Milton GW,McCarthy WH

更新日期：1985-04-01 00:00:00

abstract：:An analysis of prognostic factors in 4000 patients with cutaneous malignant melanoma at the Sydney Melanoma Unit and the University of Alabama in Birmingham has demonstrated that the histological features of the primary melanoma become less predictive of survival the more advanced the disease becomes. Thus, whilst 4 f...

journal_title：Pathology

authors： Shaw HM,Balch CM,Soong SJ,Milton GW,McCarthy WH

更新日期：1985-04-01 00:00:00

abstract：:An unusual case of gliomatosis cerebri in a 37 yr-old man is reported. He presented with a variable clinical picture. Mental changes, brain stem signs, cerebellar signs and rise in intracranial pressure were the constant findings. The postmortem findings are described and the available literature is reviewed. ...

journal_title：Pathology

authors： Balakrishnan V,Hornabrook RW,Alexander WS

更新日期：1985-01-01 00:00:00

abstract：:An enzyme-immunoassay has been developed for rapid isotyping of murine monoclonal antibodies. This assay has several advantages over the commonly used typing methods. It does not require the presence of specific antigen. Typing plates can be prepared in advance and stored frozen. Unequivocal results can be obtained in...

journal_title：Pathology

authors： Gardner ID

更新日期：1985-01-01 00:00:00

abstract：:A patient with cerebral strokes had a cardiac tumour excised. Histologically, it was an infarcted myxoma with features of a Gamna body. Findings are compared with other cardiac Gamna bodies reported in the literature. Most probably represent unusual degenerative changes in a myxoma. ...

journal_title：Pathology

authors： Coard KC,Silver MD

更新日期：1984-10-01 00:00:00